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The dominant paradigm for ECM remodeling – proteolytic cleavage. Left: when synaptic plasticity is initiated, ECM cleaving proteases such as MMP9 (Michaluk et al., 2011) may be translated and/or secreted locally at the synapse. Right: the synapse undergoes structural plasticity, and new molecules are secreted to re-stabilize the perisynaptic ECM.
