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. 2022 Mar 31;16:861800. doi: 10.3389/fncir.2022.861800

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Copyright © 2022 Mori and Sakano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An unfolded map of the neocortex and olfactory cortex (left hemisphere). A dorso-centered view is schematically shown for the exteroceptive and interoceptive sensorimotor regions. Neocortex areas are classified into the exteroceptive sensorimotor (blue) and interoceptive sensorimotor (peach) regions. The exteroceptive region includes the somatosensory (SS), primary motor (MOp), secondary motor (MOs), auditory (Aud), and visual (Vis) areas. The interoceptive region includes the gustatory (GU), visceral (VISC), agranular insular (dorsal part, AId; ventral part, AIv; and posterior part, AIp), orbital (lateral part, ORBl; ventrolateral part, ORBvl, and medial part, ORBm), infralimbic (IL), prelimbic (PL), and dorsal part of the anterior cingulate (ACAd) areas. Interoceptive sensory inputs, including taste and visceral signals reach the interoceptive sensory cortex (including GU and VISC) via the nucleus of solitary tract (NTS), parabrachial nucleus (PBN) and parvocellular parts of the ventral posteromedial thalamic nucleus (VPMpc), and ventral posterolateral thalamic nucleus (VPLpc). AIv, ORBl, and ORBvl are displaced as indicated by the arrows of broken lines to avoid overlap with the olfactory cortex. The medial map of the OB (dark orange), their tufted-cell target areas in the AON and TT (pale orange), and neocortex interoceptive areas (peach) receive the top-down attention signal during eating behavior. The lateral map of the OB (blue), their TC target areas in the AON (blue), and PPC/neocortex exteroceptive areas (pale blue) receive the top-down attention signal during food-searching behavior. This unfolded map was generated using the Allen Institute for Brain Science (2004) (https://mouse.brain-map.org/static/atlas). The midline is shown by a broken line (anterior side is left). For additional abbreviations, please see the legend to Figure 1.