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. 2022 Apr 13;5(7):e202101268. doi: 10.26508/lsa.202101268

Figure 5. Representative connectivity patterns based on PSTH profiles of holographic stimulation.

Figure 5.

(A) At 35 days post induction, two neurons close to electrodes 24 and 45 (e24 and e45) were stimulated separately by two episodes of holographic stimulation (B, C, D) or simultaneously by full-field stimulation (B). Distance between electrodes, 200 μm. (B, C, D) Peri-event raster and histograms of evoked activity in e24, e45, and e83 in response to full-field (B) or holographic (C, D) stimulation. (C) Holographic episode targeting a neuron close to e24 (C) induced a direct response with short delay at e24 and delayed response at e83 but did not affect the activity at e45. (D) Another episode targeted a neuron close to e45 (D) that evoked a direct response with short delay at e45, and indirect responses with long delay at e24 and e83. (E) Based on collective PSTH profiles of e24, e45, and e83 in response to the holographic stimulation of two individual neurons, a functional connectivity motif within this random neuronal subnetwork was extracted.