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. 2022 Mar 31;13:870283. doi: 10.3389/fimmu.2022.870283

Table 1.

Summary of immune checkpoint receptors (A) and ligands (B) covered in this review.

A B
IC receptors Cellular expression pattern Ligand Cellular expression pattern
PD-1 T cells, NKT, NK, B cells, activated monocytes, DCs. PD-L1 Hematopoietic and non-hematopoietic cells.
CTLA-4 T cells PD-L2 DCs, macrophages, peritoneal B1 cells, helper T cells, bone marrow-derived mast cells.
LAG-3 T cells, NK, B cells. Galectin-9 T cells, B cells, macrophages, mast cells.
TIM-3 T cells, DCs, macrophages, monocytes. CD112 DCs, monocytes.
TIGIT T cells, NK, Tregs. CD155 DCs, monocytes.
BTLA T cells, B cells, DCs, monocytes. B7-H3 DCs, monocytes, T cells, B cells, NK.
VISTA T cells, myeloid cells. LSECtin Myeloid cells.
2B4 T cells, NK, DCs, monocytes. Galectin-3 Macrophages, monocytes, DCs, eosinophils, mast cells, NK, activated T and B cells.
NKG2A T cells, NK.
CD160 T cells, NK, NKT.