FIGURE 2.

Risk factors for air leak onset while on spontaneous breathing during COVID-19 acute respiratory failure. Multiple logistic regression analysis showing the association between clinical, physiological, and radiological variables with the occurrence of pneumothorax and pneumomediastinum in the study cohort by means of odds ratios (open diamonds) and relative 95% confidence intervals (error bars). *p = 0.04, **p = 0.03, and ***p = 0.01. Significance was set for p < 0.05. CT, computed tomography; PSV, pressure support; PEEP, positive end-expiratory pressure; NIV, non-invasive ventilation; HFNC, high-flow nasal cannula; RICU, respiratory intensive care unit; MAP, mean arterial pressure; RR, respiratory rate; SOFA sequential organ failure assessment; BMI, body mass index.