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. 2022 Mar 31;15:858582. doi: 10.3389/fnmol.2022.858582

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Copyright © 2022 Biel, Castanza, Rutherford, Fair, Chifamba, Wester, Hester and Hevner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AUTS2 expression in developing mouse and marmoset brain. (A) By in situ hybridization, Auts2 expression is observed in multiple areas of E14.5 mouse brain, including cerebral neocortex (Ncx), hippocampus (Hp), dorsal thalamus (DT), pons, cerebellum (Cb), and medulla (Med). Sagittal section from Genepaint (https://gp3.mpg.de/). (B,C) In P7 mouse cerebellum, AUTS2 protein (red) localizes in the nuclei of calbindin + (green) Purkinje cells, and in scattered Golgi neurons (arrows). Panel (C) magnified 5× from (B). (D) In neonatal marmosets, AUTS2 is expressed in many brain regions, with highest levels in amygdala (Am). (E,F) In 1-year-old (young adult) marmosets, AUTS2 levels remain high in amygdala and dentate gyrus (DG). Data for panels (D–F) from the Marmoset Gene Atlas (https://gene-atlas.brainminds.riken.jp/).