FIGURE 1.

Preclinical evidence of effectiveness of chemotherapy in mesothelioma. The apoptosis-inducing chemotherapy agent gemcitabine (black triangles) induces in vivo regression of the mouse mesothelioma tumour line AB1-HA compared to mice treated with phosphate buffered saline alone (open squares) (A) Early treatment; tumour bearing mice were treated when tumours were small (∼10 mm²) (B) Late treatment. tumour bearing mice were treated when tumours were small (∼10 mm²). Mice were treated with five doses of gemcitabine or PBS injection at third daily intervals. Figure originally published in Nowak et al., 2002a. Cancer Research 62:2353-8.