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. 2022 Mar 31;13:858557. doi: 10.3389/fphar.2022.858557

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Copyright © 2022 Robinson, Redwood and Creaney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cross presentation is sensitive to low antigen loads. Cross presentation was assessed using the in vivo Lyons-Parish assay (Lyons and Parish, 1994), in which carboxyfluorescein succinimidyl ester (CFSE) stained neoantigen specific T cells (CL4) were intravenously injected into F1 mice bearing the melanoma tumour (B16. par) bearing totals of 19.4, 97, 194 or 388 nmol of the neoantigen CL4 in either the nucleus (N), cytoplasm (C) or supernatant (S). Proliferation of T cells in the tumor draining lymph node on day 11 is shown by the number and size of peaks to the left of the parental non-proliferating single blue peak. Figure originally published in Anyaegbu et al., 2014. PLOS One 9: e107894.