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. 2022 Mar 31;13:858557. doi: 10.3389/fphar.2022.858557

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Copyright © 2022 Robinson, Redwood and Creaney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early detection of metastatic lung disease by immune recognition versus PET-CT. To compare immune responses to neo-antigens with PET-CT in terms of sensitivity to recurrence of metastatic tumour. Mice received AB1-HA cells day 0 and AB1-HA_LUC cells intravenously on day 14. Tumours were surgically resected to mimic cancer surgery and lung tumour growth, as a measure of the appearance of metastases, was measured in an invitro imaging system (IVIS) (A) Experimental plan (B) lung tumour growth by IVIS (C) IVIS images of mice. DOS—day of surgery. Figure originally published in Fear et al., 2019. Scientific Reports 9:14,640.