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. 2021 Jul 1;56(1):69–82. doi: 10.1177/00236772211016922

Figure 4.

Figure 4.

Animals with visual phenotypes. A variety of phenotypes were observed in CRISPR G0 mice from four different projects. (a) Short faces, domed head and missing teeth were observed in 11 out of 24 animals born from a cytoplasmic CRISPR–Cas9 injection to introduce a point mutation into Csf1r. (b) Pups with hair loss and/or tufty hair across the whole body were seen in three out of 15 animals derived from a CRISPR–Cas9 pronuclear injection to introduce a point mutation in Foxn1. (c) Pup with abnormal hind legs and gait derived from CRISPR–Cas9 electroporation to introduce a point mutation into Itpr1. Hind feet point upwards and pup weight bears on hind heels, displaying abnormal movements and hopping. (d) Oedema and odd body shape were observed in all pups born from a cytoplasmic CRISPR–Cas9 injection to introduce a point mutation into Lemd2. Upon dissection, the liver was found to be enlarged.