Table 3.

Test AUC achieved by qADD, the combination of qADD and subject demographics and risk factors, and excluding (qADD+) or including radiologic descriptors (qADD++), the Brock and Mayo Clinic Models for differentiating invasive nodules from the preinvasive nodules, Benign nodules and the group of Pre-INV and Benign nodules.

Task		Invasive vs Preinvasive	Invasive vs Benign	Invasive vs Preinvasive &Benign
qADD	AUC	0.847±0.002	0.842±0.002	0.810±0.001
	Selected features	μ-Solid, σ-Solid, μ-SS, ρ-SS	σ-Solid, μ-SS, S-Nodule, S-LP	σ-Solid, μ-SS, S-LP
	AUC	0.867 ±0.002	0.888±0.001	0.852±0.001
qADD+	Selected features	μ-Solid, σ-Solid, μ-SS, ρ-SS, E-COPD	σ-Solid, μ-SS, S-Nodule, S-LP, Gender, Smoke-years, Upper-lobe	σ-Solid, μ-SS, S-LP, ρ-SS, Gender, Smoke-years, E-COPD
	vs qADD	P = 0.208	P =0.089	P =0.280
qADD++	AUC	0.901±0.001	0.909±0.001	0.877±0.001
	Selected featu s	μ-Solid, σ-Solid, μ-SS, ρ-SS, E-COPD, GGO, Spiculated	σ-Solid, μ-SS, S-Nodule, S-LP, Smoke-years, E- COPD, Size, Spiculated	σ-Solid, μ-SS, S-LP, ρ-SS, Smoke-years, E-COPD, Size
	vs qADD	P = 0.046	P =0.027	P =0.069
	vs qADD+	P = 0.102	P =0.159	P =0.096
	AUC	0.741±0.033	0.855±0.031	0.843±0.031
	Risk factors	Age, Gender, Family, Emphysema, Size, Attenuation, Upper-lobe, Spiculated.
Brock Model	vs qADD	P=0.121	P=0.185	P=0.469
	vs qADD+	P=0.039	P =0.167	P=0.770
Mayo Clinic Model	AUC	0.693±0.030	0.821±0.032	0.771±0.032
	Risk factors	Age, Smoker, Non-Lung-Cancer, Size, Upper-lobe, Spiculated.
	vs qADD	P =0.033	P =0.681	P =0.523
	vs qADD+	P =0.014	P =0.042	P =0.028
	vs Brock	P=0.242	P=0.341	P=0.012