Table 4.

Known antiviral activities of human defensins against group V viruses [21].

Virus\Defensin	HNP1	HNP2	HNP3	HNP4	HD5	HD6	HBD1	HBD2	HBD3	HBD4
Influenza A virus	Aggregates and increases neutrophil uptake of virus, inhibits PKC activation and viral envelope fusion with endosome	Aggregates and increases neutrophil uptake of virus	Aggregates and increases neutrophil uptake of virus	U	Increases neutrophil uptake of virus	U	U	U	Inhibits HA-mediated fusion and membrane protein mobility	*
HPIV	*	*	*	*	*	*	*	U	*	*
RSV	*	*	*	*	*	*	NE	Disrupt envelope	*	*
VHSV	Binds to viral envelope G protein and induce TLR3 and ISG expression	*	*	*	*	*	*	*	*	*
VSV	Prevent viral entry	*	*	*	*	*	*	*	*	*

NE: Tested HDP had no effect, U: Antiviral mechanism is undetermined,

^*:Yet to be tested.

Table shows most common result of HDP antiviral test.