Table 6.

Known antiviral activities of LL-37.

Virus	CMV	HSV-1	HSV-2	KSHV	VZV	Vaccinia	HAdV A	B	C	D	E	F	HPV
LL-37	U	Increase IFNB expression, inhibit virus binding	U	Disrupt envelope, prevent viral entrance	U	Disrupt envelope	*	NE	NE	U	NE	*	U

Virus (con.)	DENV	HCV	VEEV	Aichivirus A	Echovirus	HRV	Influenza A virus	HPIV	RSV	VHSV	VSV	HIV-I
LL-37	Binding to envelope protein	Disrupt enve lope	U	U	*	U	Disrupt envelope, increase neutrophil NET	*	Disrupt envelope, prevent viral exit	*	*	Inhibits reverse transcriptase

NE: Tested HDP had no effect, U: Antiviral mechanism is undetermined,

^*:Yet to be tested.

Table shows most common result of HDP antiviral test.