Table 7.

Direct comparisons of human HDP activity against viruses.

Virus	Direct comparison of HDP activity
HSV-1	HNP1, HNP2, and HNP3 were about equal in effectiveness
HSV-2	HNP1 and HD5 were most effective among defensins tested. HBD3 was more effective than HBD1
VZV	HBD2 and LL-37 had similar activities, but unlike with HBD2, LL-37 pre-incubation of virus and peptide before infection increased antiviral activity compared to after infection
Vaccinia	HBD2, but not HBD1 or HNP1/2 had effect. This effect was more potent than LL-37
HAdV	For HNP1 and HD5, viral species A, B1, B2, C, and E susceptible, but D and F are not. HD5 was more effective than HNP1 against HAdV5 and HAdV35. HBD1/2 and HD6 mostly ineffective. Defensins and LL-37 inhibit different species.
HPV	HD5 had highest efficacy. HBD1/2 and HD6 had no effect. HNP1-4 and LL-37 had similar efficacies
BKV	HD5 had highest efficacy. HNP1 and HBD2 had similar effect, while HBD1 had no effect
JCV	HD5 had highest efficacy. Discrepancy for activity of HNP1 and HBD1/2. No effect seen in HNP3 or HBD4
SV40	HD5 inhibited, while HNP1 and HBD1/2 did not
HCV	Mixture of HNP1-4 (about as effective as LL-37) was more effective than mixture of HBD1-5+116
Influenza A virus	HNP3, HBD1, and HBD2 did not increase IAV uptake by neutrophils, unlike HNP1/2 and HD5. HNP1/2 (with slight edge to HNP2) more effective than HBDs or LL-37. HNP1/2 work synergistically with LL-37
RSV	HBD2 had most activity while HBD1 was ineffective. LL-37 was less effective than HBD2
HIV-I	LL-37 and HNP4 are more effective than HNP1-3, most likely due to HNP4 less binding to serum. Combination of HBD2 and HBD3 was more effective than either HBD alone. Conflicting data about HBD1 activity, with HBD2/3 having more activity. HBD2 inhibits single stage infection and provides long term antiviral activity, unlike HBD1.

Comparisons are only between HDPs tested in the same experiment.