Table 2.
Bivariate analyses of 2-year survival (Kaplan Meier analysis) by clinical-histological characteristics and wide excision group.
| Total survival (95% CI) | Wide excision | ||
|---|---|---|---|
| Yes | No | ||
| Survival (95% CI) | Survival (95% CI) | ||
| All patients | 94.9 (93.6–96.1) | 97.1 (96.0–98.0) | 74.6 (66.1–81.9) |
| Gender | |||
| Male | 94.2 (92.2–95.8) | 96.1 (94.3–97.5) | 77.1 (65.6–86.3) |
| Female | 95.8 (93.9–97.2) | 98.2 (96.7–99.1) | 71.4 (57.8–82.7) |
| Age (years) | |||
| <40 | 100.0 (97.2–100.0) | 100.0 (97.1–100.0) | 100.0 (59.0–100.0) |
| 40–49 | 99.6 (97.7–99.9) | 100.0 (98.4–100.0) | 91.7 (61.5–99.8) |
| 50–59 | 99.2 (97.2–99.9) | 99.2 (97.1–99.9) | 100.0 (69.2–100.0) |
| 60–69 | 97.5 (94.6–99.0) | 97.7 (94.8–99.3) | 94.1 (71.3–99.9) |
| 70–79 | 91.8 (87.9–94.8) | 93.0 (89.0–95.9) | 82.1 (63.1–93.9) |
| 80+ | 79.4 (72.5–85.2) | 91.5 (85.0–96.0) | 51.9 (37.6–66.0) |
| Growth phase | |||
| Radial | 98.9 (96.8–99.8) | 98.8 (96.6–99.8) | 100.0 (80.5–100.0) |
| Vertical | 94.9 (93.1–96.3) | 97.2 (95.7–98.3) | 74.1 (62.8–83.4) |
| Breslow thickness | |||
| ≤ 0.75 | 98.5 (97.2–99.3) | 98.7 (97.4–99.4) | 95.3 (84.2–99.4) |
| 0.76–1.50 | 97.5 (94.8–99.0) | 98.1 (95.6–99.4) | 87.5 (61.7–98.4) |
| 1.51–3.99 | 93.9 (89.7–96.8) | 95.6 (91.5–98.0) | 76.5 (50.1–93.2) |
| ≥4.00 | 76.5 (68.4–83.5) | 88.9 (80.5–94.5) | 50.0 (34.2–65.8) |
| TILs | |||
| Absent | 93.2 (89.8–95.7) | 95.9 (92.9–98.0) | 73.7 (56.9–86.6) |
| Present | 96.6 (95.1–97.7) | 97.8 (96.5–98.7) | 81.8 (70.4–90.2) |
| Mitotic rate (mm2) | |||
| 0–2 | 97.9 (96.7–98.8) | 98.4 (97.2–99.1) | 90.6 (79.3–96.9) |
| >2 | 88.7 (84.8–91.9) | 93.9 (90.4–96.4) | 60.0 (45.2–73.6) |
| Ulceration | |||
| Absent | 97.8 (96.7–98.6) | 98.3 (97.3–99.0) | 91.0 (81.5–96.7) |
| Present | 83.5 (78.2–88.0) | 91.9 (87.0–95.4) | 53.8 (39.5–67.8) |
| Regression | |||
| Absent | 94.6 (92.5–96.3) | 97.6 (96.0–98.7) | 67.7 (54.7–79.0) |
| Present | 97.1 (94.9–98.5) | 98.2 (96.3–99.3) | 79.2 (57.8–92.9) |
| TNM (at enrollment) | |||
| I | 98.2 (97.1–99.0) | 98.5 (97.4–99.2) | 94.2 (84.1–98.8) |
| II | 89.8 (84.9–93.5) | 96.0 (91.9–98.4) | 62.5 (49.2–79.5) |
| III | 84.4 (77.3–90.0) | 89.3 (82.3–94.2) | 55.0 (31.5–76.9) |
| Histological subtype | |||
| Malignant melanoma | 91.5 (83.2–96.5) | 94.6 (86.7–98.5) | 62.5 (45.8–77.3) |
| Superficial spreading melanoma | 96.6 (95.2–97.7) | 97.7 (96.5–98.6) | 81.8 (70.4–90.2) |
| Nodular melanoma | 87.8 (82.4–92.2) | 94.7 (89.8–97.7) | 61.5 (46.6–76.6) |
| Lentigo maligna | 96.9 (83.8–99.9) | 96.3 (81.2–99.9) | 100.0 (47.8–100.0) |
| Acral-lentiginous melanoma | 90.9 (70.8–98.9) | 100.0 (80.5–100.0) | 60.0 (14.7–94.7) |
| Desmoplastic melanoma | 83.3 (35.9–99.6) | 80.0 (28.4–99.5) | 100.0 (2.5–100.0) |
| Spitzoid melanoma | 100.0 (88.4–100.0) | 100.0 (87.7–100.0) | 100.0 (15.9–100.0) |