TABLE 4.

The application of BMPs in materials.

BMP	Material(s)	Modified	Function(s)	References
rhBMP-2	Ti6Al4V	3D printing porous structure, pore size:400–600 μm, porosity:60–80%	Improved the degree of bone-scaffold bonding	Zhang T. et al. (2020)
BMP-2	Ti6Al4V	Porous structure, pore size:600 μm, prepared by a combination of MAO, calcium-phosphorus co-precipitation and electrodeposition BMP-2 coating technology (MAO-Ca/P-BMP2)	Bone induction and bone conduction capabilities, enhances the growth of cells, enables the formation of blood vessels in the implant and has a better osteogenic effect	Teng et al. (2019)
BMP-2	TNTs	Through layer-by-layer assembly technique, the sodium alginate and gentamicin and CHI were constructed on BMP 2 loaded TNTs substrate	Enhanced antibacterial ability and bone formation ability	Tao et al. (2019)
BMP-2	HA	Combination of autologous BMSCs and ABG	Enhanced stability and bone regeneration characteristics	Teotia et al. (2017), Dilogo et al. (2019)
BMP-2	NHA	NHA coating	Providing a rich active site for cell attachment, which is more conducive to the stable combination of bone and implant	Deng et al. (2017)
BMP-7	TCP	Carried BMP-7 and bisphosphonates	Improved bone defects, promoted bone healing	Bosemark et al. (2015)
	HA
BMP-2	HA	Composite scaffold, ratio: 15% HA: 85% β-TCP	Improve bone conduction and bone integration	Ishack et al. (2017)
	β-TCP
rhBMP-2	NHA	Composite scaffold	Positive effect on human MSCs implantation, proliferation and osteogenic differentiation	Wu S. et al. (2018)
	Collagen
	PLA
BMP-2	SF	Composite scaffold	Continuously and slowly release growth factors and significantly promote the osteogenic differentiation of BMSCs	Shen et al. (2016)
	NHA	SF microspheres stromal cell-derived factor-1 (SDF-1) is bound to the scaffold
BMP-2	Ti6Al4V	Layer-by-layer assembly technology, construct a bioactive multilayer structure of gelatin/CHI containing BMP-2 and fibronectin on the surface of Ti6Al4V	Beneficial to osteogenic differentiation and integration of implant and bone	Hu et al. (2012)
	CHI
BMP-6	CHI	CHI scaffolds and BMP-6 transfected rat BMSCs	Promote bone formation and cartilage formation	Kayabasi et al. (2013)
rhBMP-2	PEEK	Pedicle screw and PEEK cage	Spinal fusion	Meisel et al. (2008)
BMP-2	PEEK	Coated BMP-2 loaded phosphorylated gelatin on PEEK	Promote cell adhesion and proliferation, effectively promote osteogenic differentiation and improve biological activity	Wu J. et al. (2018)
BMP-2	PLA	Scaffold surface-modified with DA and BMP-2	Bone regeneration occurred in the skull defects of rats; the fibrous bone tended to connect to form continuous bone tissue	Zhang X. et al. (2019)
BMP-2	PLGA	DA and BMP-2 coatings	Significantly promoted in vivo bone formation in critical-sized calvarial bone defects	Ko et al. (2013)
BMP-2	PLGA	Modified the surface of the scaffold with DA	Significant promoting effect on cell adhesion and proliferation. Alkaline phosphatase activity, calcium deposition and osteogenesis are highly expressed	Zhao X. et al. (2017)
	HA