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. 2022 Apr 11;6:24705470221092734. doi: 10.1177/24705470221092734

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The association between age and glutamate neurotransmission strength as measured by energy-per-cycle (EPC). There is a significant negative correlation between age and EPC in the full cohort, as well as in the healthy and patient groups considered separately. EPC is a measure of neuronal energetic needs (V_TCAn) per glutamate/glutamine cycling (V_Cycle), which is computed from the relative carbon-13 enrichment of glutamine and glutamate during steady state of [1-¹³C]-acetate intravenous infusion. Abbreviations: PTSD: posttraumatic stress disorder.