FIGURE 2.

Temporal cortex near hippocampus of SZ patients demonstrates increased BBB permeability and selective interaction between IgGs and pyramidal neurons. (A–D) Representative immunohistochemistry images showing the detection of extravasated IgGs (brown color) in parenchyma temporal cortex surrounding hippocampus proper from SZ and Ctrl subjects. These sections were probed with biotinylated anti-human IgG antibodies. As revealed by the brown staining, once in the brain parenchyma, IgGs selectively interact with neuropil and a subset of neurons (red arrows). The temporal cortex demonstrated a greater incidence of IgGs immunoreactivity in SZ patients compared to Ctrls of similar age. The neurons without IgG immunoreactivity are denoted by black arrows. Scale bar (in μm): A = 500 and 100; B = 600 and 100; C = 700 and 100; and D = 600 and 100.