FIGURE 3.

Hippocampus proper of SZ patients demonstrates increased BBB permeability and selective interaction between IgGs and neurons. (A–D) Representative immunohistochemistry images showing the detection of extravasated IgGs (brown color) in the parenchyma of hippocampus proper from SZ and Ctrl subjects. Sections were probed with biotinylated anti-human IgG antibodies. Once in the brain parenchyma, IgGs selectively interacted with neuropil and a subset of neurons. A subset of neurons within the DG, CA1, CA2, and CA3 regions of hippocampus demonstrated selective immunoreactivity for IgGs (red arrows). The neurons without IgG immunoreactivity are denoted by black arrows. DG = dentate gyrus; CA = Cornu Ammonis. Scale bar (in μm): A = 700 and 100; B = 800 and 100; C = 700 and 100; and D = 800 and 100.