FIGURE 4.

Comparison of the extent of BBB breakdown in the hippocampus and surrounding temporal cortex of the SZ and Ctrl subjects with respect to diagnosis, age, and sex. (A) SZ subjects demonstrated a significantly higher hippocampal and temporal cortex IgG leaked area fraction than Ctrls. (B) Correlation coefficients of Ctrls and SZ between IgG leaked area fraction and age. Comparison of SZ vs. Ctrls subdivided by middle- and advanced-aged groups (C) or gender (D) to assess for exploratory inter-and intra-group BBB leakage differences. *p < 0.05, ^**p < 0.01, with false discovery rate (q < 0.05) to correct for multiple comparisons where appropriate.