Table 1.

Five RCTs and one observational study with data characterising arterial BP during propofol sedation for colonoscopy. BIS, bispectral index SBP, systolic BP; TCI, target-controlled infusion.

Study	Study design and intervention	Number of procedures available for analysis	Available BP data	Measurement interval (min)	BP information used in analysis	Hypotension criteria used in analysis
Padmanabhan and colleagues11 (2009)	RCT; propofol sedation with or without midazolam with or without fentanyl	200	Lowest SBP during colonoscopy	2.5	Lowest SBP during colonoscopy	Hypotension=lowest SBP <90 mm Hg
Allen and colleagues12 (2015)	RCT; light vs deep (BIS guided) sedation with propofol and fentanyl	199	Occurrence of hypotension	Unknown	Hypotension yes/no	Hypotension=MAP 20% below baseline, or systolic pressure <90 mm Hg, or diastolic pressure <50 mm Hg
Leslie and colleagues13 (2006)	RCT; propofol sedation and 1.5 or 15 ml kg−1 of Hartmann's solution	160	Lowest SBP during colonoscopy	2.5	Lowest SBP; hypotension yes/no	Hypotension=lowest SBP below 90 mm Hg
Leslie and colleagues14 (2016)	RCT; propofol sedation and 2 or 20 ml kg−1 of Plasma-Lyte 148	150	Lowest SBP during colonoscopy	2.5	Lowest SBP; hypotension yes/no	Hypotension=lowest SBP below 90 mm Hg
Stonell and colleagues15 (2006)	RCT; patient-controlled vs anaesthetist-controlled propofol sedation	40	All BP measurements during colonoscopy	3	Lowest SBP; hypotension yes/no	Hypotension=lowest SBP below 90 mm Hg
Barends and colleagues16 (2020)	Observational study of TCI sedation with propofol and remifentanil	2937 (various procedures; 190 colonoscopies)	All BP measurements during colonoscopy	2.5	Lowest SBP; hypotension yes/no	Hypotension=lowest SBP below 90 mm Hg