Table 8.
Drug doses and hypotension in included studies. Data are mean (standard deviation) or median [range].
| Author (publication year) | Propofol dose (mg) | Comparator | Comparator dose (mg) | Opioid | Opioid dose (mcg) | Hypotension, n (%) |
|---|---|---|---|---|---|---|
| Adigun and colleagues17 (2019) | 471 (10) | Fentanyl | 57 (13) | 6 (19) | ||
| Midazolam | 2.5 | Pentazocine | 17.65 (5.8) | 2 (7) | ||
| Bastaki and colleagues18 (2013) | 153 (53) | 3 (6) | ||||
| Midazolam | 7.6 (2.7) | Fentanyl | 50 | 0 (0) | ||
| Chen and colleagues19 (2020) | 96 | Fentanyl | 64 (11) | 97 (51) | ||
| Remimazolam | 5 | Fentanyl | 63 (11) | 46 (24) | ||
| Eberl and colleagues20 (2014) | 442 (177) | Alfentanil | 232 (127) | 56 (93) | ||
| Midazolam | 3.9 (1.5) | Fentanyl | 67 (29) | 21 (35) | ||
| Ekmekçi and colleagues21 (2017) | 100 mcg kg−1 min−1 | Remifentanil | 73.1 | 2 (4) | ||
| Midazolam | 2 | Meperidine | 20 000 | 1 (2) | ||
| Fanti and colleagues22 (2015) | 110 (47) | Fentanyl | 71 (15) | 1 (1) | ||
| Midazolam | 2.9 (1.0) | Fentanyl | 72 (19) | 3 (4) | ||
| Gurbulak and colleagues23 (2014) | 118 (32) | Midazolam | 2.5 | Fentanyl | 50 | 22 (36) |
| Midazolam | 6.5 (1.1) | Fentanyl/meperidine | 50/30 500 (5600) | 17 (27) | ||
| Heuss24 (2012) | 131 [70–260] | Alfentanil | 4 mcg kg−1 | 17 (42) | ||
| Midazolam | 5 [4–7] | Alfentanil | 4 mcg kg−1 | 17 (41) | ||
| Karanth and colleagues25 (2018) | [2–3] mg kg−1+infusion | Fentanyl | 29 | 4 (13) | ||
| Dexmedetomidine | 1 mcg kg−1+infusion | Fentanyl | 29 | 17 (57) | ||
| Kim and colleagues26 (2021) | 82 (30) | 1 (1) | ||||
| Midazolam (bolus) | 4.8 (1.5) | Meperidine | 50 000 | 0 (0) | ||
| Midazolam (titrated) | 4.4 (1.5) | Meperidine | 50 000 | 1 (1) | ||
| Lee and colleagues27 (2019) | 0.5 mg kg−1 | Midazolam | 2.9 (0.7) | 42 (42) | ||
| Etomidate/midazolam | 0.1 mg kg−1/3.0 (0.6) | 27 (27) | ||||
| Padmanabhan and colleagues28,35 (2017; 2020) | 251.3 (76.9) | 3 (1) | ||||
| Midazolam | 6.9 (2.1) | Fentanyl | 149 (64) | 8 (3) | ||
| Paspatis and colleagues29 (2002) | 80 [40–150] | Midazolam | [2–3] | 24 (38) | ||
| Midazolam | 5 [3–7] | Meperidine | 75 000 [50 000–125 000] | 17 (30) | ||
| Schroeder and colleagues30 (2016) | 341 (122.8) | 3 (2) | ||||
| Midazolam | 5.7 (1.4) | Fentanyl | 138.8 (41.6) | 2 (2) | ||
| Sipe and colleagues31 (2002) | 218 (94) | 0 (0) | ||||
| Midazolam | 4.7 (1.5) | Meperidine | 89 700 (29 100) | 3 (8) | ||
| Steenholdt and colleagues32 (2020) | 342 (139) | 4 (6) | ||||
| Midazolam | 2.4 (0.5) | Fentanyl | 60 (20) | 3 (5) | ||
| Toklu and colleagues33 (2009) | 159.8 | Remifentanil | 170 | 16 (53) | ||
| Etomidate | 20.2 | Remifentanil | 223.2 | 2 (7) | ||
| Ulmer and colleagues34 (2003) | 277 (105) | 4 (8) | ||||
| Midazolam | 7.2 (2.6) | Fentanyl | 117 (30) | 4 (8) |