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. 2022 Apr 14;17:37. doi: 10.1186/s13000-022-01217-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A, The cysts are lined by gastrointestinal-type mucinous epithelium with variable degrees of epithelial proliferation. B, Higher magnification demonstrating mucinous epithelium with goblet cells and nuclear atypia. C, There are several foci of bland, monotonous epithelioid cells arranged in solid nests or tubular/acinar architecture in reactive stroma adjacent to mucinous epithelium. The bland epithelioid cells can also be seen in adjacent mucinous glands (arrow). D, Florid stromal micronests are seen focally and cells emanating from a mucinous gland are present (arrow). E, Pancytokeratin (AE1/AE3) immunostaining highlights both mucinous epithelium and the stromal micronests. F, Synaptophysin immunostaining highlights the endocrine cell micronests in the stroma as well as intraepithelial neuroendocrine cells in adjacent mucinous glands