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. 2022 Apr 14;20:120. doi: 10.1186/s12957-022-02555-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — GO and KEGG functional annotation analyses of 19 differentially expressed ferroptosis-related genes. A Bubble chart of significantly enriched GO term. B The circle shows the scatter map of the specified gene in each GO term. The red circles and blue circles represent upregulation and downregulation genes, respectively. The higher the Z-score value, the higher the enrichment pathway expression. C Bubble chart of significantly enriched KEGG pathways. D The circle shows the scatter map of the specified gene in each KEGG pathway. The red circles and blue circles represent upregulation and downregulation genes, respectively. The higher the Z-score value, the higher the enrichment pathway expression. E The pie chart of the correlation between differentially expressed FRGs and classical cancer pathways. Red color represents activates pathways and green color represents inhibits pathways. F Network diagram of the correlation between differentially expressed FRGs and classical cancer pathways. Red color represents activates pathways and blue color represents inhibits pathways