Table 2.

Correlations between hormones and RANK pathway gene expression in postmenopausal women

Gene	Mean (Range)	Age	BMI	PRL	ESR1	PGR	STAT1	STAT5	RANK	RANKL	OPG	TNFRSF13B	TNFRSF18
PRL	5.81 (4.60–6.83)	0.05	− 0.05	1.00	0.01	0.25	0.25	0.39	− 0.16	0.02	0.28	− 0.18	0.24
		p = 0.34	p = 0.28		p = 0.79	p < 0.01	p < 0.01	p < 0.01	p < 0.01	p = 0.70	p < 0.01	p < 0.01	p < 0.01
ESR1	5.38 (4.42–7.42)	0.01	0.07		1.00	0.43	− 0.11	− 0.09	0.27	0.08	0.41	0.20	0.22
		p = 0.99	p = 0.17			p < 0.01	p = 0.04	p = 0.08	p < 0.01	p = 0.10	p < 0.01	p < 0.01	p < 0.01
PGR	4.4 (3.08–7.00)	0.08	− 0.04			1.00	− 0.15	− 0.05	0.25	0.10	0.65	0.10	0.30
		p = 0.20	p = 0.42				p < 0.01	p = 0.36	p < 0.01	p = 0.05	p < 0.01	p = 0.04	p < 0.01
STAT1	14.62 (10.79–16.86)	0.04	− 0.07				1.00	0.59	− 0.17	− 0.02	− 0.15	− 0.22	0.20
		p = 0.43	p = 0.18					p < 0.01	p < 0.01	p = 0.65	p < 0.01	p < 0.01	p < 0.01
STAT5	11.93 (8.09–12.99)	0.03	0.06					1.00	− 0.21	− 0.06	− 0.08	− 0.06	0.35
		p = 0.50	p = 0.22						p < 0.01	p = 0.24	p = 0.11	p = 0.25	p < 0.01
RANK	6.33 (5.72–6.93)	− 0.02	− 0.18						1.00	0.15	0.17	0.19	0.32
		p = 0.64	p < 0.01							p < 0.01	p < 0.01	p < 0.01	p < 0.01
RANKL	2.93 (2.16–3.70)	0.07	− 0.16							1.00	0.17	− 0.01	0.14
		p = 0.19	p < 0.01								p < 0.01	p = 0.90	p < 0.01
OPG	4.12 (3.57–4.67)	0.04	− 0.10								1.00	0.07	0.25
		p = 0.40	p = 0.04									p = 0.14	p < 0.01
TNFRSF13B	6.70 (6.09–7.31)	− 0.12	− 0.12									1.00	0.23
		p = 0.02	p = 0.02										p < 0.01
TNFRSF18	7.42 (7.04–7.80)	0.01	− 0.13										1.00
		p = 0.92	p = 0.01

Pearson’s correlation coefficients were calculated. Gene expression levels were log2 transformed

BMI Body Mass Index (kg/m²)

^*Statistically significant correlations (p < 0.05) are in bold