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. 2022 Mar 31;13:677202. doi: 10.3389/fendo.2022.677202

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Copyright © 2022 Zhang, Hu, An, Wang, Liu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The volcano plots of 45 serum lipids levels between control and T2DM groups. A total of 15 lipids exhibited significant differential abundance (P < 0.05) with 2 of them down-regulated and 13 of them up-regulated when comparing T2DM patients to control. Mann-Whitney U tests were used to calculate statistical significance. Differentially lipid species with different fold changes were individually color-coded with up-regulated lipids in red, down-regulated in blue, and not-significant in grey. LPC, lysophosphatidylcholine; PE, phosphatidylethanolamine; LPE, lysophosphatidylethanolamine; PC, phosphatidylcholine; SM, sphingomyelin; Cer, ceramide.