Table 3.

Clinical trials using AMPs for treatments.

The study	Condition	Interventions	Locations	Status
Clinical and metagenomic investigation of antimicrobial peptide gel in periodontal treatment	Periodontitis	Drug: 0.85% synthetic antimicrobial peptide TAPS-18 Drug: 0.9% normal saline	Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia	Completed
Antimicrobial peptides in periodontitis	Periodontal disease: chronic periodontitis	Other: periodontal smears	Chu de Reims, Reims, France	Completed
Liver-enriched antimicrobial peptide 2	Type 2 diabetes	Biological: liver-enriched antimicrobial peptide 2 Other: placebo	Center for Clinical Metabolic Research, Hellerup, Denmark	Completed
Role of antimicrobial peptides in host defense against vaccinia virus	Atopic dermatitis		National Jewish Health, Denver, CO, United States	Completed
The estrogen impact on overactive bladder syndrome: female pelvic floor microbiomes and antimicrobial peptides	Overactive bladder	Drug: conjugated estrogen	Loyola University Medical Center, Maywood, IL, United States	Completed
First time in man trial for friulimicin B	Community-acquired pneumonia Staphylococcal skin infections	Drug: friulimicin B	Swiss Pharma Contract Ltd., Basel, Switzerland	Completed
Safety of a single dose of 5 mg of hLF1-11 given to autologous haematopoietic stem cell transplant recipients	Hematopoietic stem cell transplantation Bacterial infections and mycoses	Drug: human lactoferrin peptide 1–11	UMC St. Radboud, Nijmegen, Gelderland, Netherlands	Completed
PK/PD of EA-230 during endotoxemia	Endotoxemia Systemic inflammatory response	Drug: EA-230 Drug: endotoxin Drug: placebo	Intensive Care, Research Unit, Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands	Completed
A study to evaluate the microbiology, safety and tolerability of C16G2 dental strip application	Dental caries	Drug: C16G2 strip Other: placebo strip	John F. Pittaway, DMD, Kalispell, MT, United States Jacqueline Kleven, DDS, Bedford, TX, United States Anthony Henegar, DDS, PA, Irving, TX, United States	Completed
A study of DPK-060 to investigate clinical safety and efficacy in patients with acute external otitis	Acute otitis externa	Drug: DPK-060 Drug: placebo for DPK-060 ear drops	ProMore Pharma	Completed
Phase 2B dose-ranging study of PAC113 mouthrinse in HIV seropositive individuals with oral candidiasis	Oral candidiasis	Drug: PAC113	Drug: PAC113	Completed
A study to evaluate safety, tolerability and efficacy of Lytixar™ (LTX-109) on uncomplicated, Gram-positive, skin infection	Gram-positive, skin infections Mild Eczema/Dermatoses Atopic dermatitis	Drug: LTX-109	Debreceni Egyetem Orvos-és Egészségtudományi, Debrecen, Hungary Miskolci Semmelweis Ignác Egészegügyi Központ és, Miskolc, Hungary Pécsi Tudományegyetem általános Orvostudom’nyi Centum, Pécs, Hungary Szeged University Hospital, Szeged, Hungary	Completed
Effects of a 12-week combined exercise program on ghrelins in obese adolescent girls	Ghrelin	Other: combined exercise program Other: control	Pusan National University Yangsan Hospital, Yangsan, Gyeungsangnam-do, South Korea	Completed
Effects of smoking and vitamin D3 on the levels of human cathelicidin peptide LL-37	Periodontitis	Other: LL-37 levels in gingival crevicular fluid Other: serum vitamin D3 levels Other: clinical parameters	-	Completed
DOM-INNATE: study of SGX942 for the treatment of oral mucositis in patients with concomitant chemoradiation therapy for head and neck cancer	Squamous cell carcinoma of the oral cavity and oropharynx Oral mucositis	Drug: SGX942 Drug: placebo	Arizona Clinical Research Center, Tucson, AZ, United States Loma Linda University Health, Loma Linda, CA, United States Pomona Valley Hospital Medical Center, Pomona, CA, United States (and 50 more…)	Active, not recruiting
Study of PXL01 vs. placebo to inhibit adhesion formation after flexor tendon surgery	Surgical adhesions	Drug: PXL01 Drug: placebo	Dept. of Hand Surgery, Aalborg Hospital, Aalborg, Denmark Dept. of Hand Surgery, Odense University Hospital, Odense, Denmark Klinik für Handchirurgie der Herz- und Gefäß-Klinik GmbH, Bad Neustadt, Germany (and 12 more…)	Completed
Pharmacokinetics and safety of POL7080 in patients with renal impairment	Renal impairment	Drug: POL7080	CRS Clinical Research Services Kiel GmbH, Kiel, Germany	Completed
A study of ascending single doses of surotomycin in healthy participants (MK-4261-008)	Clostridium difficile associated diarrhea (CDAD)	Drug: surotomycin Drug: placebo	-	Completed
Trial of iseganan in prevention of ventilator-associated pneumonia	Pneumonia	Drug: iseganan hydrochloride	Barnes-Jewish Hospital, St. Louis, MO, United States	Completed
MSI-78 topical cream vs. oral ofloxacin in the treatment of infected diabetic ulcers	Diabetic foot ulcers	Drug: ofloxacin Drug: MSI-78	Seattle VA Medical Center, Seattle, WA, United States	Completed