FIGURE 3.
Path models testing the primary hypothesis that therapeutic alliance would lead to better depression scores 6 weeks following psychedelic-assisted psychotherapy. Serial mediation of therapeutic alliance via pre-session rapport and A) Emotional Breakthrough and B) Mystical-type experiences were supported by the models. Depression severity at the 6-weeks Endpoint was adjusted for baseline depression scores (p > 0.1, not displayed in the figure), which by itself accounts for R 2 = 0.12, i.e., 12% of variance in the final outcome. Numbers represent standardised regression coefficients for significant (solid) and non-significant (dashed) paths. **indicates p < 0.01, *** p < 0.001.