TABLE 1.

Genotype‐independent sex differences in body and brain weight across 4–12 months of age

Genotype	Body weight (g)	Brain weight (g)
4‐month‐old
2N Male (n = 3)	35.157 ± 1.126	0.470 ± 0.012
3N Male (n = 3)	31.92 ± 0.497	0.460 ± 0.010
2N Female (n = 3)	25.307 ± 1.182	0.490 ± 0.012
3N Female (n = 3)	27.960 ± 2.874	0.490 ± 0.015
Sex effect p‐value	0.0033**	0.1086
7‐ to 8‐month‐old
2N Male (n = 4)	45.602 ± 3.276	0.457 ± 0.016
3N Male (n = 3)	40.95 ± 1.499	0.457 ± 0.013
2N Female (n = 3)	46.307 ± 3.486	0.503 ± 0.009
3N Female (n = 3)	35.533 ± 5.196	0.500 ± 0.006
Sex effect p‐value	0.5313	0.0073**
12‐month‐old
2N Male (n = 3)	44.927 ± 2.449	0.497 ± 0.009
3N Male (n = 3)	44.293 ± 1.225	0.487 ± 0.003
2N Female (n = 3)	35.783 ± 1.932	0.477 ± 0.003
3N Female (n = 4)	39.090 ± 2.294	0.477 ± 0.010
Sex effect p‐value	0.0083**	0.1042

Only main effects of sex are shown as there were no significant genotype main effects and no interactions. 4‐month‐old female mice show a significantly lower body weight than male counterparts. 7‐8‐month‐old female mice show a significantly higher brain weight than male counterparts. 12‐month‐old female mice show a significantly lower body weight than male mice. Italicized are p‐values. Bold p‐value indicates statistically significant p‐values (**p < 0.01). Data reported as means ± SEM.