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. 2022 Mar 31;13:798022. doi: 10.3389/fimmu.2022.798022

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Copyright © 2022 Shen, Xie, Xu, Yang and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NET score is closely associated with major cancer hallmarks, especially inflammatory response. (A) NET score is strongly correlated with cancer hallmarks (inner circle) and immune infiltrating cells (outer circle). The circle diameter corresponds to the Pearson correlation value. (B) Chemotaxis genes are strongly differentially expressed in the high and low NET score groups. SKCM and BLCA are presented as examples. (C) Higher NET scores predict a poorer response to immune checkpoint blockade therapy.