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. 2022 Mar 31;13:798022. doi: 10.3389/fimmu.2022.798022

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Copyright © 2022 Shen, Xie, Xu, Yang and Qin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of SPP1 as a key NET-related gene facilitating NET-related malignancy. (A) A heatmap showing the NET-related genes with the highest correlation and differential expression between cancers with favorable or risk NET-related survival. (B) A volcano plot showing expression differences. (C) Representative Pearson correlation values between NET score and pan-cancerous SPP1 expression. (D) A univariate Cox proportional hazard model showing the hazard ratios for death in the NETs_high_gene_high group compared with the NETs_low_gene_low group in a pan-cancer cohort.