Fig. 3.

Superimposed structure of ACE2 in WT and VOCs showing the relative variation in the receptor binding domains. Interfacial region of RBD and ACE2 in (a) Alpha, (b) Beta, (c) Gamma, and (d) Delta. When the structure is rotated 90° in (e) Alpha, (f) Beta, (g) Gamma, and (h) Delta. Relative displacement was observed in Beta and Delta (shown as arrows). (WT: RBD in cyan, ACE2 in pink; Alpha RBD in green; Beta RBD in Blue; Gamma RBD in Red; Delta RBD in Magenta). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)