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. Author manuscript; available in PMC: 2022 Apr 14.
Published in final edited form as: N Engl J Med. 2021 Dec 23;385(26):2451–2462. doi: 10.1056/NEJMra1913421

Figure 2. Convergence of Tissue Transplantation and Repair.

Figure 2.

Multiple immune cells contribute to tissue repair and transplant tolerance. T cells, highlighted here, contribute to both tissue repair and transplant tolerance through production of the immunosuppressive cytokines interleukin-10, transforming growth factor β (TGF-β), and interleukin-35 by regulatory T cells (Tregs) and in the context of a wound secrete growth factors specific to the tissue. Other T-cell types, such as type 2 helper T (Th2) cells, promote tissue repair through production of cytokines, including interleukin-4.