Table 4.

Sex-specific Differences and Recommendations in Guidelines

Clinical Practice Document	Noted Sex-specific Differences	Noted Sex-specific Recommendations	Knowledge Gaps
2013 ACC/AHA STEMI Guideline	-30% are women -remain undertreated	-none	-prehospital delay -bleeding risks
2014 ACC/AHA NSTE-ACS	-pregnancy: revascularization if life-threatening complications	-early invasive strategy for high risk features	-antithrombotic dosing -MINOCA
2012, 2014 update ACC/AHA Stable Ischemic heart disease	-none for PCI, medications, CABG	-Avoid estrogen replacement therapy in post-menopausal women	-nonobstructive disease diagnosis, treatment
2011 ACC/AHA PCI	-higher in hospital mortality -higher procedural complications	-none	-vascular access and bleeding risks
2011 ACC/AHA CABG	-higher perioperative morbidity/mortality -similar long term outcomes	-none -most data extrapolated from men	-mitigating bleeding risks -improving complete revascularization
2020 ESC ACS without STEMI	-none. noted to follow same treatment	-careful antithrombotic dosing periprocedural	-nonobstructive disease