FIGURE 11.

Relative distribution of ATP1A1, ATP1A3, and ATP1B1 gene transcripts in the human cochlea based on RNAscope^® ISH. Gene transcription may suggest that the lateral pathway of K⁺ cycling from the organ of Corti is dominant. Type I spiral ganglion cells contain the largest number of mRNA gene puncta. They overcame signal counts in marginal cells 20 times and type II fibrocytes nine times. The number of counts in the ganglion cells was probably higher since many puncta were concentrated in clusters due to their large number near the plasmalemma. Results of quantitative analysis of ATP1B1 signal counts per cell in different cellular domains of the human cochlea are shown and in Table 2.