Fig. 14.
BP for kidney injury cure. (a) Schematic demonstration of BP nanosheet accumulation directed to the kidneys and alleviation of acute kidney injury (AKI) by reacting with reactive oxygen species (ROS) to safeguard renal function. The scavenging efficiency of BP for various ROS species including (b) hydrogen peroxide (H2O2), (c) hydroxyl radical (•OH), and (d) scavenging, and superoxide (•O2−). Track of BP nanosheet biodistribution after injection of cy5-BP nanosheets by in vivo imaging of cy5 intensity at different time points in (e) AKI mice and (f) healthy mice. (g) Hematoxylin and eosin staining of kidney tissues with different treatment (top row) and in situ TUNEL assay images with green fluorescence showing the cellular apoptosis (bottom row). Reproduced with permission.128 Copyright 2020, American Chemical Society.