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. Author manuscript; available in PMC: 2022 Apr 14.
Published in final edited form as: Biomater Sci. 2021 Feb 23;9(8):2768–2803. doi: 10.1039/d0bm01972k

Fig. 16.

Fig. 16

(a) Schematic demonstration of BP encapsulation in nanovesicles, stem cells, or self-assembled polymers for photothermal based cancer treatment. (b) The photothermal cancer immunotherapy using encapsulated BPQD-RMNVs with aPD-1 component. Reproduced with permission.310 Copyright 2019, Elsevier. (c) Schematic demonstration of CpG-loaded BPQD system (BPNVs-CpG) fabrication through self-assembly of BPQD conjugated with pyrene-PEG and ROS sensitive pyrene-PPS polymer, and the photodynamic immunotherapy for cancer. (d) In vivo PA imaging of tumors over time under NIR or no NIR irradiation in 4T1 tumor-bearing BALB/c mice injected with BPNVs-CpG. (e) Images for pulmonary nodules obtained from a metastasis animal model and (f) quantitative analysis of metastatic nodules observed in the mouse lungs with varied NIR treatments (group 1: PBS, group 2: PBS + NIR irradiation, group 3: CpG alone, group 4: BPNVs + NIR irradiation, and group 5: BPNVs-CpG + NIR irradiation). Reproduced with permission.311 Copyright 2019, John Wiley and Sons.