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. 2021 Aug 13;163(5):861–877. doi: 10.1097/j.pain.0000000000002438

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 5. — Effect of antibiotic regimen and FMT on gut permeability. (A) Elisa assay for LBP in plasma samples. Analysis of occludin (B) and Zo-1(C) gene expression on colon samples by RT-quantitative PCR. The mRNA expression was normalized to β-actin, and fold changes were expressed in comparison with the control group. (A) Each value is the mean ± SEM of 3 or 5 (vehicle + vehicle group) animals per group; (B and C) Each value is the mean ± SEM of 6 (donors, day 7 and day 32) or 4 (day 46) animals per group. Statistical analysis was one-way analysis of variance followed by Bonferroni post hoc comparison. *P < 0.05 and **P < 0.01 vs vehicle-treated animals. abx, antibiotics; CTR, control animals; DNBS, dinitrobenzenesulfonic acid; FMT, faecal microbiota transplantation LBP, lipopolysaccharide-binding protein; mRNA, messenger RNA.