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. 2022 Mar 31;13:852563. doi: 10.3389/fimmu.2022.852563

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Copyright © 2022 Ziemssen, Arnold, Alvarez, Cross, Willi, Li, Kukkaro, Kropshofer, Ramanathan, Merschhemke, Kieseier, Su, Häring, Hauser, Kappos and Kuhle

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation between baseline sNfL concentrations and on-study whole and regional brain volume change as illustrated in scatter plots over the specified time period in either the overall population (A: baseline to M12; B: baseline to M24), or in the subgroup of recently diagnosed, treatment-naive patients (C: baseline to M12; D: baseline to M24). Random coefficients model adjusted for study, treatment, region, and baseline sNfL category as fixed effects factors; time, baseline number of Gd+ T1 lesions, baseline T2 volume, and normalized brain volume (whole or regional) at baseline as continuous covariates; and treatment-by-time-by-baseline sNfL category interaction and the three corresponding two-way interactions. Gd+, gadolinium-enhancing; M, month; NfL, neurofilament light chain.