Table 1.
Demographics and clinical characteristics at baseline.
| HC | NAEB | EA | |
|---|---|---|---|
| n=14 | n=15 | n=15 | |
| Sex, F/M | 8/6 | 5/10 | 9/6 |
| Age, y | 29.2 ± 6.4 | 46.7 ± 14.6# | 44.5 ± 10.9# |
| BMI | 20.1 ± 2.5 | 23.5 ± 2.9* | 23.9 ± 3.9* |
| FeNO. ppb | 16.0 (9.0, 23.0) | 34.0 (23.0, 61.0) # | 50.0 (36.0, 79.0) # |
| FEV1, pred% | 95.6 ± 8.2 | 100.8 ± 12.8‡ | 81.6 ± 22.3 |
| FEV1/FVC, % | 87.7 ± 8.0 | 83.4 ± 6.6‡ | 69.8 ± 12.1# |
| MMEF, pred% | 84.0 ± 24.6 | 88.7 ± 25.5‡ | 44.0 ± 21.9# |
| Induced Sputum | |||
| TCC, x106/mL | 2.3 (0.8-5.8) | 2.8 (1.4-13.2) | 2.3 (0.9-11.2) |
| Neutrophils, % | 60.2 (40.5, 65.5) | 59.0 (26.0, 77.5) | 49.0 (21.5, 78.0) |
| Macrophage, % | 37.5 (23.8, 58.5) | 21.0 (8.5, 47.0) | 11.8 (1.5, 53.5) |
| Eosinophils, % | 0.2 (0.0, 1.0) | 4.5 (3.5, 18.5)# | 16.0 (8.2, 37.8)# |
| Lymphocyte, % | 1.5 (0.8, 2.2) | 1.5 (1.0, 11.5) | 2.0 (1.0, 2.5) |
| Blood | |||
| Eosinophils, % | 2.2 ± 1.6 | 5.2 ± 3.2* | 6.4 ± 3.2# |
| Eosinophils, (109/L) | 0.1 ± 0.1 | 0.3 ± 0.2* | 0.4 ± 0.2# |
| Total IgE (KU/L) | 55.7 (27.4, 89.9) | 98.7 (50.6, 180.0) | 107.2 (67.2, 327.0) |
Age, BMI, FeNO, FEV1pred, FEV1/FVC, MMEFpred and blood eosinophil are presented as mean ± SD and analyzed by one-way ANOVA. Sputum different counts and Total IgE are presented as median (IQR); sputum TCC is presented as median (min–max) and calculated by Kruskal–Wallis test. The distribution of sex was calculated by chi-square test. Compared with EA: ‡p < 0.01; compared with healthy control: *p < 0.05, #p < 0.01.