Table 2.
Changes of biomarkers after one-month treatment in NAEB and EA Group.
| NAEB (n=9) | EA (n=10) | |||||
|---|---|---|---|---|---|---|
| Baseline | Follow-up | p-value | Baseline | Follow-up | p-value | |
| FeNO, ppb | 59(53) | 25(11)* | 0.020 | 46.5(57.3) | 28.5(51.7) | 0.416 |
| LCQ | 16.2 ± 2.4 | 20.4 ± 3.5* | 0.049 | NA | NA | NA |
| VAS | 50(30) | 10(5)# | <0.001 | NA | NA | NA |
| ACT | NA | NA | NA | 19.4 ± 3.7 | 23.3 ± 1.7* | 0.014 |
| Sputum Eos, % | 5.0(37.8) | 3.8(10.3) | 0.148 | 16.4(36) | 5(41.6) | 0.734 |
| Sputum Eos (109/L) | 0.20(0.80) | 0.18(0.40) | 0.461 | 0.41(1.70) | 0.10(0.70) | 0.160 |
| Blood Eos (109/L) | 0.3(0.2) | 0.2(0.1)* | 0.050 | 0.4(0.2) | 0.3(0.2) | 0.456 |
| Blood HPC (cells/ml) | 939(822) | 843(1,726) | 0.820 | 1553(1,697) | 775(1,160)* | 0.014 |
| Blood EoP (cells/ml) | 68(229) | 76(143) | 0.637 | 145(328) | 84 (90)* | 0.020 |
| NAEB (n=7) | EA (n=6) | |||||
| Sputum HPC (cells/ml) | 1345(11476) | 887(1370) | 0.297 | 742(2051) | 432(1574) | 0.900 |
| Sputum EoP (cells/ml) | 169(275) | 7(200) | 0.297 | 69(294) | 31(41) | 0.438 |
FeNO, LCQ, VAS, and ACT were presented as mean ± SD and analyzed by pair t-test. Other variables were presented as median (IQR) calculated by Wilcoxon matched-pairs sign rank test. Absolute cell numbers enumerated by means of flow cytometry are presented as cells per milliliter. Compared with baseline: *p < 0.05, #p < 0.01