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. 2022 Mar 31;13:860418. doi: 10.3389/fimmu.2022.860418

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Copyright © 2022 Ruggiero, Pascucci, Cotugno, Domínguez-Rodríguez, Rinaldi, Tagarro, Rojo, Foster, Bamford, De Rossi, Nastouli, Klein, Morrocchi, Fatou, Smolen, Ozonoff, Di Pastena, Luzuriaga, Steen, Giaquinto, Goulder, Rossi, Levy, Pahwa, Palma and the EPIICAL Consortium

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of exhausted T-cells are positively associated with hyperactivated B-cells. In (A) a cartoon showing the main findings of the figures are pictured. In (B) Heatmap plot showing Spearman correlations between exhausted T-cells and hyperactivated B-cells. Only significant correlations are shown with red indicating positive correlations and Blue the negative ones. The colored scale going between 1 and -1 indicates the rho values. DN, double negative; AM, activated memory. Significance was set at p<0.05.