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. 2022 Mar 24;3(3):zqac015. doi: 10.1093/function/zqac015

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© The Author(s) 2022. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Receptor-ligand interaction analysis reveals age-related differences to chemotactic signaling during the recovery from disuse. Receptor-ligand network analysis of adult (A-C) and aged (D-F) muscle between weight-bearing (WB), recovery following disuse (RE), and recovery with mechanotherapy (REM) conditions (cutoff for significant interactions: q-value<0.001). The number of significant interactions is indicated both by color intensity and edge thickness. The top five RL interactions for each age and condition indicated to the right of interaction plot. Blue arrow indicates top cellular interactors with directionality indicating ligand→receptor.