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Mechanotherapy reprograms macrophage dynamics in the aged similar to that of adult macrophages recovering from disuse. (A) Pathway “activity scores” between ages and conditions calculated using AuCell36 and visualized by heatmap (high “activity” shown in red, low “activity” shown in blue). Trajectory inference analysis using Monocle 3.0 displayed by sample (B), by “drivers” of pseudotime trajectories (C), and highlighted by aged RE and REM samples (D).
