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. 2022 Mar 31;10:846446. doi: 10.3389/fbioe.2022.846446

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Copyright © 2022 Liu, Hou, Zhu, Zhang, Chen, Yang, Luo, Wu and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Polarizing microscope images of SNs, SPNs, and SSPNs before and after being heated from 25°C to 65°C (scale bar = 20 μm). (B) In vitro US images of SSPNs at 25°C, 60°C, and 65°C and (C) average gray values of SSPNs (n = 3). (D) T2-weighted MR images of SSPNs and SPIOs at different Fe concentrations using a 1.5-T MRI scanner. (E) T2 relaxation rates of SSPNs and SPIOs corresponding to (D).