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AppG–F mice suitable for studies of BACE1 inhibitors. The AppG–F line is devoid of the Swedish mutation that influences the β-secretase activity and elevates the quantity of CTFβ. (The AppG–F line instead carries a wild-type sequence: KM.) The AppG–F model would be appropriate for use in preclinical studies of β-secretase inhibitors without the interference of the Swedish mutation.
