Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 31;16:807473. doi: 10.3389/fnins.2022.807473

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Sasaguri, Hashimoto, Watamura, Sato, Takamura, Nagata, Tsubuki, Ohshima, Yoshiki, Sato, Kumita, Sasaki, Kitazume, Nilsson, Winblad, Saito, Iwata and Saido.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Somatostatin receptor subtypes 1 and 4 (SST_1/4) regulate the Aβ-degrading enzyme NEP. The neuropeptide somatostatin (SRIF) was identified as a regulator of NEP activity through in vitro screening. Subsequent analysis of the effect of genetic deletion of somatostatin receptor (SST) subtypes in mice revealed that SST₁ and SST₄ regulate NEP in a redundant manner. This was further confirmed by concurrently deleting SST₁ and SST₄ in App KI mice, which aggravated the Aβ pathology. SST_1/4 can be either a combination of SST₁ and SST₄ homodimers or an SST₁/SST₄ heterodimer.