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Role of ENSA in the regulation of NEP activity. Schematic illustration of the mechanism describing NEP activity in the brain. ENSA, a downstream protein of SST-SST1/4 signaling, plays a role as a ligand of the KATP channel composed of sulfonylurea receptor subunit 1 (SUR1) and inwardly rectifying K+ channel 6.2 (Kir6.2), resulting in the activation of NEP. SST1/4 can be either a combination of SST1 and SST4 homodimers or an SST1/SST4 heterodimer.
