Fig. 8.

Examples of synthetic MTase inhibitors. LLY-283 is a selective inhibitor of MTase PRMT5, which is responsible for the formation of most mono- and dimethylated arginine residues in proteins [57]; compound EPZ-5676, an inhibitor of MTase DOT1L, which is responsible for methylation of lysine-79 in histone H3 [49, 51, 52]; a potential inhibitor of MTases Nsp14 and Nsp16 of SARS-Cov-2, which are responsible for methylation of the mRNA cap [56]; bisubstrate inhibitor of nicotinamide-N-MTase (NNMT), an enzyme responsible for the formation of N-methylnicodinamide from nicotinamide [50]; N-propylsinfungin, a sinfungin derivative, selectively inhibiting MTase SETD2, which methylates lysine residues in proteins [53, 54].