Table 1.
Multiple imputation and sensitivity analysis of missing data.
| Variable | Missing proportion (%) | Before imputation | After imputation | Statistical | P |
|---|---|---|---|---|---|
| Sex | 0.0 | ||||
| Age | 0.0 | ||||
| Pathogenesis | 0.0 | ||||
| Respiratory rate | 0.0 | ||||
| Heart rate | 0.0 | ||||
| FIO2 | 0.0 | ||||
| Heart failure | 0.0 | ||||
| Renal failure | 0.0 | ||||
| SAPS II score | 0.0 | ||||
| SOFA score | 0.0 | ||||
| Bicarbonate input | 0.0 | ||||
| Ventilation | 0.0 | ||||
| Vital status | 0.0 | ||||
| Survival time | 0.0 | ||||
| ICU type | 0.0 | ||||
| Immune function impairment | 0.0 | ||||
| Creatinine | 0.0 | ||||
| TBIL | 24.1 | 0.60 (0.40, 1.20) | 0.70 (0.40, 1.60) | Z = 1.608 | 0.150 |
| AST | 23.6 | 45.00 (28.00, 98.00) | 47.00 (27.00, 109.00) | Z = 1.104 | 0.270 |
| ALT | 23.4 | 31.00 (18.00, 80.00) | 30.00 (18.00, 76.00) | Z = −0.394 | 0.694 |
| SaO2 | 20.0 | 88.25 ± 14.01 | 87.95 ± 13.99 | t = 0.560 | 0.575 |
| PaO2 | 20.3 | 169.00 (97.00, 292.00) | 156.00 (93.00, 281.00) | Z = −1.572 | 0.089 |
| Lactate | 17.9 | 1.90 (1.30, 3.10) | 2.00 (1.30, 3.20) | Z = 1.340 | 0.180 |
| INR | 0.8 | 1.30 (1.10, 1.60) | 1.30 (1.10, 1.60) | Z = 0.213 | 0.831 |
| Ventilation time | 0.8 | 7.00 (3.00, 13.00) | 7.00 (3.00, 14.00) | Z = 0.824 | 0.410 |
| pH | 0.3 | 7.34 ± 0.12 | 7.34 ± 0.12 | t = 0.220 | 0.824 |
| MAP | 0.2 | 84.40 ± 17.29 | 84.55 ± 17.28 | t = −0.270 | 0.784 |
| GCS score | 0.2 | 9.00 (5.00, 13.00) | 9.00 (5.00, 13.00) | Z = −0.290 | 0.772 |
| Potassium | 0.2 | 4.24 ± 0.80 | 4.24 ± 0.80 | t = −0.080 | 0.937 |
| SBP | 0.1 | 125.00 ± 26.30 | 124.99 ± 26.28 | t = 0.010 | 0.994 |
| Sodium | 0.1 | 138.85 ± 4.80 | 138.83 ± 4.79 | t = 0.080 | 0.937 |
| RBC | 0.1 | 3.68 ± 0.74 | 3.68 ± 0.74 | t = −0.070 | 0.945 |
| Hemoglobin | 0.1 | 11.09 ± 2.18 | 11.09 ± 2.18 | t = −0.060 | 0.956 |
| WBC | 0.1 | 12.70 (9.20, 17.30) | 12.70 (9.20, 17.40) | Z = 0.032 | 0.975 |
| Bicarbonate | 0.1 | 23.35 ± 4.71 | 23.35 ± 4.70 | t = 0.020 | 0.988 |
| Hematocrit | 0.1 | 32.89 ± 6.32 | 32.90 ± 6.32 | t = −0.040 | 0.971 |
| PLT | 0.1 | 219.00 (153.00, 301.00) | 219.00 (153.00, 301.00) | Z = −0.015 | 0.988 |
| BUN | 0.1 | 19.00 (14.00, 30.00) | 19.00 (14.00, 30.00) | Z = 0.013 | 0.990 |
Note. SAPS II: Simplified Acute Physiology Score II; SOFA score: Sequential Organ Failure Assessment score; ICU: intensive care unit; TBIL: total bilirubin; AST: aspartate transaminase; ALT: alanine transaminase; INR: international normalized ratio; MAP: mean arterial pressure; GCS: Glasgow Coma Scale; RBC: red blood cell; WBC: white blood cell; PLT: platelet; BUN: blood urea nitrogen.